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Description
GLP 1 receptor agonists are often discussed as weight loss medications. The physiology is broader than that. They affect glucose regulation, appetite signaling, gastric emptying, cardiovascular outcomes, and kidney health. That's why clinicians Effect of combination treatment with glucagon like peptide 1 receptor agonists and sodium glucose cotransporter 2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study The BMJ Tirzepatide, a dual GLP 1 and GIP receptor agonist, promotes bone loss in obese mice via gut microbial related metabolites ScienceDirect Glucagon like peptide 1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study The BMJ
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4.6 ★★★★★
Based on 781 reviews
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Product Reviews
★★★★★ 5
Great
Size: Medium, Number of Items: 1
I need something that was soft for my three year old and this ball is super great, it not only is the right size but it also fits in his mouth just right. Although he is a super aggressive chewer, the ball toy hasn't been totally destroyed yet and it is easy on his gums. The ball is so durable that got two of these toys just for fun.
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Reviewed in the United States on May 10, 2026
★★★★★ 5
The best!
UPDATE: 08/05/2025 - This is still one of my dog's 2 fav training/play toys. A couple of notes:
1. This is not a chew toy. If your pup is chewing up the rope, that's on you. That being said, you can get 100' of the poly cord rope at Home Depot for like $4.98. You can make nearly 100 ropes out of 100'. How hard is it to replace the rope?????
2. My pup is a now 15 month old Malinois. His original balls, purchase in September 2024 are still in everyday, multiple times per day, play. I did get careless and leave one where he got it and chew the rope. Easily replaced. Nothing to fret over. Yes, that was on me!
3.The foam ball is virtually indestructible! Replace the rope!
4. I noticed the price for the yellow large went from $12 each to $24. THIS will cause me to go elsewhere if they doubled in price. I LOVE these balls but not that much. I noticed they have a new yellow ball that has a strap vs. a rope. I might try that if I need one, but I have 6 of these balls, 2 never used yet, 2 that are virtually new looking, and 2 that have been in play since september 2024. I don't think I'll be buying more any time soon, but if I do need more, I hope they haven't gone up to $24 each.
One of my top, go-to training tools. Quality is great other than the shrink wrap around the string joint. It's junk but not essential.
Great tug and fetch toy. Essential to teaching a good "out" command (2 are recommended for this).
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Reviewed in the United States on January 11, 2025
★★★★★ 5
Best dog ball
This is our go to dog toy for our German shepherd. its great for training in sports as well as outings at the beach, considering it floats! Never had him destroy one, so its extremely durable. I like that its a bright color so its easier to locate when i accidently let go of the rope too late and end up whipping it 20 ft into the woods. Easy to clean, all around just a great toy. Also love the large size as having a dog accidently lodge a ball into its throat is a real fear of mine, I do not have to worry about that with this toy. I should also mention the rope is a must, as touching a slobbery ball isn't the greatest feeling in the world and it puts your hands out of harms way. I will forever order these.
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Reviewed in the United States on September 7, 2025
★★★★★ 4
Great ball, bad rope
Size: Medium, Number of Items: 1, Size: Medium, Number of Items: 1
My dog and I love the starmark ball on a rope tug toys. While this is one of the best tug toys we have found, I am continually disappointed with the quality of the rope. The plastic sleeve comes off the first day, and after that the stitching begins to weaken until the rope ends come apart and the rope slides out of the ball. Is there a way to improve this design so that this toy lasts longer? My dog is not left alone with the toy, it is only used as an interactive tug toy as a training reward.
I am updating my review now several months later. I reinforced the rope with a paracord braid and the toy now lasts a very long time. My dog and I play with this toy everyday on our morning hike. He is a large German Shepherd with high ball drive. He carries this ball in his mouth several miles on our morning hike. We play fetch in the fields near our home and in the lake beyond the fields with this toy every day. This toy is his reward in obedience training and we play a lot of tug with it every day. Reinforcing the handle has made a huge difference as the toy lasts and lasts now with the improved rope. Great ball, we will always have a collection of them at our house!
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Reviewed in the United States on September 19, 2020
★★★★★ 5
Great for training and play!
Size: Medium, Number of Items: 1
My German shepherd love this toy! Great to take on walks with you as light weight and can fit in your pocket. Stands up to the toughest of play. Great as reward toy for training in place of treats! We always have one on hand at home or out and about!
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Reviewed in the United States on March 18, 2026
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